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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Immunogenetics. 2010 Jul 22;62(9):623–631. doi: 10.1007/s00251-010-0464-x

Fig. 5.

Fig. 5

A hypothetical evolutionary scenario for VCBP2/5 haplotype diversification via sequence change: (1) duplication generated at least three VCBP2/5 genes, each consisting of seven exons; (2) differentiation of gene loci; (3) exchange has occurred between genes 5a and 5b in EX1–2 as well as in EX5–7. EX1–EX3 have undergone genetic exchange between genes 2b and 5b. EX1 of the 5b gene was replaced by unrelated or distantly related genes. All or part of EX7 was exchanged between 5a and 5b. The VCBP 5b locus is used as a reference (except for the unusual EX1), likely owing to more functional constraint resulting in less polymorphism at this locus