Table 1.

Cytotoxicity of eudistomins Y₁–Y₇ 23–29 and derivatives 16–22 (Scheme 3) in vitro ^a (μM).

Compound	IC50 (μM) b	Compound	IC50 (μM) b
	MDA-231 c		MDA-231 c
16	31.1	23	56.3
17	15.8	24	51.1
18	30.2	25	63.6
19	31.2	26	15.6
20	28.1	27	32.1
21	20.1	28	28.1
22	25.9	29	37.2

^a Data represent the mean values of three independent determinations; ^b Cytotoxicity as IC₅₀ for each cell line, is the concentration of compound that causes a 50% growth inhibition to untreated cells using the MTT assay; ^c Breast carcinoma cell lines MDA-231.