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. 2013 May 21;11(5):1677–1692. doi: 10.3390/md11051677

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Plitidepsin increases the level of phosphorylated JNK in spleens of K562 tumor-bearing mice. Mice xenografted with K562 cells received a single administration of plitidepsin (APL; 200 μg/kg) and either immediately (0 min), or at the indicated times after injection, were sacrificed (5 mice/group). (A) Western blot analysis of total (JNK) and phosphorylated JNK (p-JNK) in spleens excised from the animals. Actin was used as loading control. K, K562 cells; K + APL, plitidepsin-treated K562 cells. (B) Quantification of p-JNK levels (normalized to those of total JNK) at the indicated times after APL administration and related to that of sample vehicle-treated K562 at the indicated times after APL administration. Mean ± SEM values of each group of animals are shown.