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Dose- and time-response treatments with the three Cotylorhiza extract fractions on the gap junction intercellular communication (GJIC) in MCF-7 (A); and HEKa cell cultures (B). UP, Upper phase; IP, Intermediate Phase; LP, Lower Phase.Data are expressed as percentage of the relative control and represent the mean ± SD of three independent experiments (n = 6). *** p ≤ 0.01.
