Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Study design, with randomization schemes for part 1 and part 2. A, Part 1 included two panels of subjects (three subjects per group) with repeat dosing and crossover design. B, Part 2 doses were determined using a Bayesian dose-response analysis and administered in the crossover design. A:P = active:placebo dosing ratio; MTD = maximally tolerated dose up to 1.6 mg.
