Figure 4.

Effect of camostat on nasal PD perfusion tracings. Tracings were obtained in the target nostril about 2 h following intranasal administration of camostat or placebo. A, Representative nasal PD tracings for a subject treated with camostat 1.6 mg and placebo. The nostril was sequentially perfused with Ringer, amiloride (100 μmol/L), Cl-free gluconate, Cl-free gluconate plus isoproterenol 100 μmol/L, and ATP 10 μmol/L. B, Summary data indicating the mean PD of that shown in A for subjects treated with camostat 1.6 mg and placebo. The Ringer PD and change in PD following amiloride perfusion each reflect sodium transport, whereas the change with Cl-free (zero Cl⁻), Cl-free isoproterenol and ATP reflect anion conductance. *P = .05; ^aP = .09. Data are mean ± SEM. ATP = adenosine triphosphate. See Figure 3 legend for expansion of other abbreviation.