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Type I and II endometrial cancers.
| Type I endometrial cancers | Type II endometrial cancers | |
|---|---|---|
| Hormonal impact | Estrogen dependent | Estrogen independent |
| Histology | Endometrioid adenocarcinomas | Clear-cell, serous, uterine carcinosarcomas |
| Patient population | Younger, obese, perimenopausal | Older, thin, postmenopausal |
| Distribution | 85% | 15% |
| Prognosis | Better differentiated | More aggressive, proportionally higher mortality |
| Genetic mutations | Kras, PTEN, MLH1 | p53, erbB2 |
