Table 7.

NCCN guidelines for adjuvant treatment of early-stage endometrial cancer.

Stage	Adverse risk factorsa		Grade
		1	2	3
IA	Not present	Observe	Observe or brachytherapy	Observe or brachytherapy
	Present	Observe or brachytherapy	Observe or brachytherapy ± WPRT (category 2B)	Observe or brachytherapy ± WPRT
IB	Not present	Observe or brachytherapy	Observe or brachytherapy	Observe or brachytherapy ± WPRT
	Present	Observe or brachytherapy ± WPRT	Observe or brachytherapy ± WPRT	WPRT ± brachytherapy ± chemotherapy (category 2B) or observe (category 2B)

^aRisk factors: age >60; lymphovascular space invasion (LVSI); Tumor size >2 cm; lower uterine (cervical/glandular) involvement.

WPRT: whole pelvic radiation therapy.