Table 1.
Effect of chronic treatment with NaHS or PPG on plasma lipid profile.
| Group | n | Total cholesterol (mM) | HDL (mM) | LDL (mM) | Trigylceride (mM) |
|---|---|---|---|---|---|
| WT control | 3–5 | 3.1 ± 0.03 | 1.3 ± 0.2 | 0.2 ± 0.02 | 2.2 ± 0.2 |
| Fat-fed ApoE−/− | |||||
| Untreated | 4–6 | 32.1 ± 5.9*** | 2.5 ± 0.4 | 6.5 ± 1.0*** | 2.0 ± 0.4 |
| NaHS (10 μmol/kg/day) | 4–7 | 32.3 ± 3.4*** | 2.4 ± 0.2 | 7.9 ± 1.0*** | 1.9 ± 0.3 |
| NaHS (100 μmol/kg/day) | 6-7 | 37.7 ± 2.2*** | 1.6 ± 0.1 | 6.9 ± 0.4*** | 1.9 ± 0.2 |
| PPG 30 mg/kg/day | 3–6 | 33.1 ± 3.2*** | 2.4 ± 0.5 | 8.3 ± 1.1*** | 2.4 ± 0.3 |
***P < 0.0001, ANOVA, C57 compared with untreated fat-fed ApoE−/−.