Table 3.
Correlation between 35S-methionine pulse labelling, immunoblotting and respiratory complex activities in six patients
| Patient | 35S-methionine pulse labelling | Immunoblotting | Respiratory complex activity |
Muscle histochemistry |
|
|---|---|---|---|---|---|
| SDH+ | COX– | ||||
| P9 | COXI faster migration | COXI truncated band | I + II/III + IV ↓ | – | +++ |
| P10 | Normal or overall ↑ | COXI, COXII, NDUFB8 ↑ | I + III + IV ↓ | ++ | ++ |
| P12 | ND1, ND4, ND5 ↓ | COXI, COXII, NDUFB8 ↓ | I + IV ↓ | + | – |
| P19 | Overall ↓ | COXI, COXII, NDUFB8 ↓ | I + IV ↓ | + | – |
| P32 | Only ND4 ↓ | COXI, COXII, NDUFB8 ↑ | I + II/III ↓ | – | – |
| P36 | Overall ↓ | COXI, COXII, NDUFB8 ↑ | I + IV ↓ (liver) | + | – |