Table 3.

Topiramate and cognitive tests in rats exposed to neuronal insult.

	Highest daily dose of topiramate(mg/kg/day)	Model of injury	Cognitive test	Effect on learning or memory compared with injured rats without topiramate administration	Details
Cha et al.[2002]	80	Seizure	Water maze	+	Spatial learning improved in weanlings
Zhao et al.[2005]	80	Seizure	Water maze, open field	+	Spatial learning improved
Frisch et al.[2007]	20 and 100 once	Seizure	Water maze	+	Spatial learning improved only in the 20 mg/kg group
Hoover et al.[2004]	30	Traumatic brain injury	Water maze	_	Learning was impaired 1 month post-injury
Shatskikh et al. [2009]	40	Seizure	Water maze	+	Spatial learning modestly improved
McDaniel et al. [2007]	Not reported	Intracerebral hemorrhage	Water maze	+	Spatial learning improved in early training
Mikati et al.[2011]	30	Hypoxia-induced seizure	Water maze	+	Prevented long-term memory impairment