TABLE 7.

INCREASING PLASMA IL-1 RECEPTOR ANTAGONIST LEVELS ARE ASSOCIATED WITH INCREASING COPIES OF RS315952

	rs315952 Genotype
	CC (n = 25)	CT (n = 51)	TT (n = 61)	P Value	Regression P Value
IL1RA, pg/ml, additive	11,351 (2,000–24,587)	5,176 (1,008–16,558)	3,725 (1,229–8,185)	0.071*	0.048
IL1RA, pg/ml, recessive	11,351 (2,000–24,587)	3,880 (1,193–11,832)		0.049†	0.045

Definition of abbreviation: IL1RA = IL-1 receptor antagonist.

Levels are shown as median (interquartile range). The additive model tests three levels of genotype in an ordered fashion (CC versus CT versus TT), whereas the recessive model tests homozygous minor allele versus nonhomozygous (CC versus CT + TT). Plasma levels were then quantile transformed and tested by linear regression for an association with the C allele, which was statistically significant for both genetic models.

^*Plasma levels compared between genotype by nonparametric test of trend, assuming an additive genetic model.

^†Plasma levels compared between genotype by rank-sum test, assuming a recessive model of action.