TABLE 3.

THE LIST OF POTENTIALLY IMPORTANT METABOLITES BASED ON THE ORTHOGONAL PARTIAL LEAST SQUARES DISCRIMINANT ANALYSIS REGRESSION COEFFICIENTS (P < 0.05) FOR MODELS

	SIRS vs. Healthy			Septic vs. Healthy			Septic vs. SIRS
	Infants	Toddlers	School Age	Infants	Toddlers	School Age	Infants	Toddlers	School Age
2-Aminobutyrate	↓		↓	↓	↓
2-Hydroxybutyrate				↑	↑	↑	↑		↑
2-Hydroxyisobutyrate	↑
2-Hydroxyisovalerate	↑			↑	↑	↑
2-Methylglutarate					↑
2-Oxoisocaproate	↑			↑		↑			↑
3-Hydroxybutyrate		↑			↑
3-Hydroxyisovalerate	↑
Acetate		↓		↓
Acetone		↑	↑		↑
Adipate				↓			↓
Alanine			↓				↓		↑
Arginine	↓					↑		↑	↑
Asparagine									↑
Betaine					↑
Carnitine						↑
Citrate	↓	↓	↓			↓		↑
Creatine						↑			↑
Creatine phosphate	↑					↑			↑
Creatinine	↑			↑		↑			↑
Ethanol			↓						↑
Glucose				↑	↑		↑	↑
Glutamate							↓
Glutamine	↓		↓		↓
Glycerol	↓						↑		↑
Glycine	↑						↓
Histidine						↑			↑
Hypoxanthine							↓
Isobutyrate		↑			↑
Isoleucine							↓
Lactate	↑	↑		↑	↑	↑	↓		↑
Methanol	↓	↓	↓						↑
Methionine							↓
Myo-Inositol	↑					↑
O-Acetylcarnitine						↑
Ornithine							↓
Phenylalanine	↑	↑			↑	↑			↑
Pyroglutamate	↑
Pyruvate	↑						↓
Serine							↓
Suberate	↑						↓
Taurine		↑					↓	↓	↑
Threonine				↓			↓
Tyrosine	↓
Urea		↓

Definition of abbreviations: ICU = intensive care unit; SIRS = systemic inflammatory response syndrome.

SIRS/ICU control subjects vs. healthy, patients with septic shock vs. healthy, patients with septic shock vs. SIRS/ICU control subjects within infants, toddlers, and school-age children. Arrows indicate significant change in the concentration (upward arrow = increased; downward arrow = decreased); empty cells indicate no significant change.