TABLE 5.

COMPARISON OF SENSITIVITY, SPECIFICITY, POSITIVE PREDICTIVE VALUE, NEGATIVE PREDICTIVE VALUE, ACCURACY, AND AREA UNDER A RECEIVER OPERATOR CURVE RESULTS FOR MODELS

Model	Data	Sensitivity : Specificity	PPV:NPV	ACC	AUROC
Septic shock vs. SIRS/ICU control subjects	Metabolomics	0.78 ± 0.11 : 0.72 ± 0.14	0.80:0.68	0.75	0.82
	PCT	0.56 ± 0.16 : 0.94 ± 0.08	0.91:0.66	0.74	0.80
	PRISM III-APS	0.83 ± 0.10 : 0.56 ± 0.16	0.74:0.69	0.72	0.80
Nonsurvivors vs. survivors (age- and sex-matched samples)	Metabolomics	0.80 ± 0.25 : 0.90 ± 0.19	0.89:0.82	0.85	0.91
	PCT	0.29 ± 0.33 : 0.57 ± 0.37	0.40:0.44	0.43	0.51
	PRISM III-APS	0.70 ± 0.28 : 0.80 ± 0.25	0.78:0.73	0.75	0.85

Definition of abbreviations: ACC = accuracy; AUROC = area under a receiver operator curve; ICU = intensive care unit; NPV = negative predictive value; PCT = procalcitonin; PPV = positive predictive value; PRISM III-APS = Pediatric Risk of Mortality III-Acute Physiology Score; SIRS = systemic inflammatory response syndrome.

Patients with septic shock vs. SIRS/ICU control subjects and nonsurvivors vs. survivors (age- and sex-matched samples) based on metabolomics, PCT and PRISM III-APS data.