Figure 2.

CCR2 deficiency leads to increased severity of hypoxia-induced pulmonary arterial hypertension (PAH). (A) Measurements of right ventricular (RV) systolic pressure (RVSP) in WT and Ccr2^−/− mice. After 4 weeks of exposure to hypoxia, Ccr2^−/− mice (n = 22) have increased RVSP compared with WT (n = 27). (B) Measurements of RV/[LV + S] ratio in WT and Ccr2^−/− mice. With hypoxic stress, Ccr2^−/− mice exhibit increased RV hypertrophy. (C) Measurement of heart rate (bpm, beats per minute). Compared with hypoxic WT mice, hypoxic Ccr2^−/− mice have more tachycardia. *P < 0.05; **P < 0.01; ***P < 0.001.