Scheme 1.
Reagents and conditions: (a) BOC2O, NaOH, H2O, Dioxane; (b) 4-ClPhNH2, EDC, DMAP, DCM; (c) TFA, DCM, −10 °C; (d) i. m-R1PhCO2H, EDC, DMAP, DCM/DMF; ii. Amberlyst-15, DCM.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.