Figure 2.

(A) The mean ceruloplasmin (Cp) level significantly decreases in all patients from baseline of 29.7–14.2 mg/dl while on treatment with tetrathiomolybdate (TM). The horizontal line indicates mean; box, standard deviation; whiskers, minimum to maximum values. (B) Mean Cp remains suppressed over time only in copper-depleted patients. The shaded area indicates target for copper depletion. (C) More triple-negative breast cancer patients achieve copper depletion than other molecular subtypes. The percentage of patients copper-depleted is noted above the bar.