Table 2.
Fetal Axial Skeletal Defects
| Saline | Deprenyl | HU (400mg/kg) | HU (400mg/kg) + deprenyl | HU (600mg/kg) | HU (600mg/kg) + deprenyl | |
|---|---|---|---|---|---|---|
| Fetuses (litters) | 32(9) | 19(9) | 20(5) | 16(8) | 15(9) | 21(8) |
| Abnormal supraoccipital | — | — | 1(1) | — | — | 3(3) |
| Abnormal thoracic vertebrae | — | — | 1(8) | — | — | — |
| Abnormal sternebrae | — | — | — | 1(1) | — | 1(1) |
| Forked ribs | — | — | — | 1(1) | — | — |
| Abnormal forelimbs | — | — | — | 2(1) | 2(2) | 3(3) |
| Abnormal lumbosacral vertebrae | 2(2) | 2(1) | 8(6)*** | 15(8)***,† | ||
| Abnormal hindlimbs | — | — | 2(2) | 2(2) | 5(5)** | 13(8)***,† |
| Amelia | — | — | — | — | — | 1(1) |
| Femur hypoplasia | — | — | 1(1) | — | 1(1) | — |
| Tibial aplasia/hypoplasia | — | — | 1(1) | — | 1(1) | — |
| Fibula bent | — | — | — | — | 1(1) | — |
| Digital aplasia/hypoplasia | — | — | 2(2) | 2(2) | 5(5)** | 13(8)***,† |
| Tail aplasia/hypoplasia | — | 2(2) | 8(5)*** | 8(8)*** | 13(9)*** | 18(8)*** |
Note. HU, hydroxyurea. The data are presented as number of fetuses (litters). Statistical analysis was done with two-way ANOVA and Dunnett’s post-hoc test.
Asterisks (**) and (***) denote a statistically significant difference (p < 0.01) and (p < 0.0001), respectively, compared with controls. † denotes a significant difference between the hydroxyurea-treated groups in the presence or absence of deprenyl (p < 0.05).