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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: J Nucl Med. 2010 Jul 21;51(8):1226–1233. doi: 10.2967/jnumed.109.072447

FIGURE 2.

FIGURE 2

Time-activity curve (A) and associated blood plasma nicotine concentration (B) from representative subject. (A) Equilibrium was reached before subject had smoked to satiety: for this subject, average percentage change was 3.1%/h in thalamus, 3.9%/h in striatum, 0.1%/h in mean cortex, and 2.7%/h in cerebellum. Two to 5 h after smoker had smoked to satiety, there appeared to be little change in kBq/cm3, suggesting that pseudoequilibrium state was achieved. (B) Highest nicotine concentration was observed at 20 min after initiation of tobacco smoking.