Table 3.
Protein networks involving ACR adducted proteins. The column containing “entities in network” indicates those identified as having ACR adducts in the particular network. For example, there were 7 ACR adducted proteins detected in this study that regulate the expression of angiotensinogen.
| Protein Seed | Overlap | Entities in Network |
p-value |
|---|---|---|---|
| Low-density lipoprotein |
5 | ICAM1,HRAS,PPARG, MMP14,FDX1 |
0.005 |
| Leptin | 6 | ICAM1,PPARG,MMP14, COL3A1,FDX1,MC3R |
0.006 |
| Angiotensinogen | 7 | ICAM1,PPARG,MMP14,LRP2, COL3A1,THBS4,FDX1 |
0.013 |
| MAPK3 | 5 | MAPK1,ICAM1,PPARG, MMP14,COL3A1 |
0.015 |
| MAPK1 | 7 | MAPK1,ICAM1,PPARG, MMP14,LRP2,COL3A1,ABCA7 |
0.018 |
| FGF2 | 6 | ICAM1,PPARG,MMP14, FIGF,PTPN11,FDX1 |
0.030 |
| Ras | 5 | ICAM1,PPARG, MMP14,PRDX1,SPZ1 |
0.031 |
| MAPK14 | 5 | ICAM1,PPARG, ANXA1,COL3A1,PRDX1 |
0.043 |
| Peroxiredoxin-1a | 19 | MAPK1,ICAM1,PPARG,MMP14,PTPN11,LRP2,PPP1R12A,COL3A1,GRIK3, THBS4,LIMK1,PIK3CB,ACP1,CAMK1,PRDX1,SPZ1,SYNGAP1,FDX1,ABCA7 | P<0.001 |
| Protein 14-3-3a | 6 | PTPN11,PPP1R12A,LIMK1,PIK3CB,CAMK1,PRDX1 | P<0.001 |
indicates that entities in network are binding partners. All others are involved in expression networks. Abbreviations are as follows; ABCA7, ATP-binding cassette, sub-family A (ABC1), member 7; ACP1, acid phosphatase 1, soluble; ANXA1, annexin A1; CAMK1, calcium/calmodulin-dependent protein kinase I; COL3A1, collagen, type III, alpha 1; FDX1, ferredoxin 1; FIGF, c-fos induced growth factor (vascular endothelial growth factor D); GRIK3, glutamate receptor, ionotropic, kainate 3; HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog ;ICAM1, intercellular adhesion molecule 1;LIMK1, LIM domain kinase 1; LRP2, low density lipoprotein receptor-related protein 2; MAPK1, mitogen-activated protein kinase 1;MC3R, melanocortin 3 receptor;MMP14, matrix metallopeptidase 14 (membrane-inserted); PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ;PPARG, peroxisome proliferator-activated receptor gamma;PPP1R12A, protein phosphatase 1, regulatory subunit 12A ;PRDX1, peroxiredoxin 1;PTPN11, protein tyrosine phosphatase, non-receptor type 11;SPZ1, spermatogenic leucine zipper 1; SYNGAP1, synaptic Ras GTPase activating protein 1;THBS4, thrombospondin 4.