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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Nat Rev Cancer. 2013 Mar 14;13(4):258–271. doi: 10.1038/nrc3484

Figure 3. The effects of PEDF on tumour progression.

Figure 3

A linear representation of different pigment epithelium-derived factor (PEDF) targets that form a concerted set of activities to inhibit cancer progression. PEDF can differentiate tumours to a less-malignant phenotype. Tumour cells secrete angiogenic factors to activate endothelial cells. PEDF can block angiogenesis-mediated activities and neovascularization. PEDF can also block tumour migration, invasion and metastasis.