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. 2013 May 24;288(27):19516–19527. doi: 10.1074/jbc.M113.476911

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Drs2 functions are restored with a P + 4 leucine (F511L) when combined with substitutions corresponding to Atp8a1 residues. A, in Drs2, substitutions of Atp8a1 residues combined with F511L partially restores the ability to complement a dnf1,2,3Δdrs2Δ strain. The same Drs2 variants restore cold resistance to drs2Δ (B) and support membrane PS asymmetry (E) better than Drs2 F511L alone. Substituting the individual residues also allows Drs2 to support growth of dnf1,2,3Δdrs2Δ (C) and cold-resistant growth of drs2Δ (D). 5-FOA, 5-fluoroorotic acid.