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Compound SW155246 SAR. A, chemical structures of compound SW155246 and analogs are shown. SW155246-1 has had the hydroxyl group removed and SW155246-2 has had a methyl group added to the oxygen at the 1-position of the naphthyl ring. B, hDNMT1 filter-binding assay with 10 μm of each compound is shown. Each bar represents the average of three independent experiments. Conditions are described under “Experimental Procedures.”
