FIGURE 3.

Mother's milk-induced impairment of de novo βOHB production in neonatal SCOT-KO liver. A, hepatic fractional ¹³C enrichments of βOHB (left), total βOHB pools (middle), and ¹³C-βOHB concentration (right) 20 min after intraperitoneal injection of sodium [1,2,3,4-¹³C₄]octanoate (10 μmol/g of body weight) in P1 mice. n = 6–8/group. B, fractional ¹³C enrichments of βOHB (left), total βOHB pools (middle), and ¹³C-βOHB concentration (right) 20 min after intraperitoneal injection of sodium [1,2,3,4-¹³C₄]octanoate (10 μmol/g of body weight) in livers of unfed P0 mice. n = 6/group. C, plasma total ketone body (TKB) concentration (millimolar), measured in P0 wild-type and SCOT-KO mice prior to the onset of suckling. n = 4/group. D, plasma total ketone body concentration (millimolar), measured in P0 wild-type and SCOT-KO mice within 2 h after the onset of suckling. The distributions of d-βOHB and AcAc are shown. n = 8–10/group. †, p < 0.05 for AcAc; *, p < 0.05 for βOHB. E, fractional ¹³C enrichments of βOHB (left), total βOHB pools (middle), and ¹³C-βOHB concentration (right) 20 min after intraperitoneal injection of sodium [1,2,3,4-¹³C₄]octanoate (10 μmol/g of body weight) in milk-fed P0 mice. n = 6–7/group. ***, p < 0.001 by Student's t test. Error bars, S.E.