TABLE 5.

Multiple sequence alignments

A, alignment of ECDs of human hormone receptors GIPr, GLP1r, and GCGr. The numbering is as per the crystal structure of GIPr ECD in complex with Gipg013 Fab. Highlighted residues are involved in the binding to Gipg013 Fab. Residues in boldface type are conserved residues. Protein sequences were obtained from the following Uniprot entries: human GIPr, P48546; human GCGr, P47871; human GLP-1r, P43220. B, alignment for comparison of contact residues for Gipg013 Fab in GIPr ECD of human, dog, mouse, and rat GIPr. The numbering is as per the crystal structure of GIPr ECD in complex with Gipg013 Fab. Highlighted residues are involved in the binding to Gipg013 Fab. Residues in boldface type are conserved residues. Protein sequences were obtained from the following Uniprot entries: human GIPr, P48546; canine GIPr, E2RIK5; mouse GIPr, Q0P543; rat GIPr, P43219.