FIGURE 3.

Compound 1 only stimulates NS3h encoded by HCV genotype 1b strains. A, relative rates of ATP hydrolysis catalyzed in the presence of various concentrations of compound 1 by NS3h proteins derived from various HCV genotypes and dengue virus (DENV). B, relative rates of ATP hydrolysis catalyzed by various NS3h enzymes in the presence of 100 μm of compound 1. Data are expressed relative to control reactions containing the same proteins that were performed in the absence of compound 1. All reactions were performed in triplicate, points are average values, and error bars depict standard deviations.