Table 2.
Summary statistics for gene expression levels among the patient population
| |
|
Mortality |
Recurrence |
||||
|---|---|---|---|---|---|---|---|
| NameϮ | Median (Q25, Q75) | HR (95% CI) | P-value | Adj P-value | HR (95% CI) | P-value | Adj P-value |
|
RABEP1 |
-0.27 (-1.43, 1.05) |
0.77 (0.67, 0.87) |
0.000 |
0.011 |
0.79 (0.7, 0.9) |
0.000 |
0.042 |
|
PGR* |
0.38 (-2.3, 3.09) |
0.91 (0.86, 0.95) |
0.000 |
0.014 |
0.92 (0.87, 0.97) |
0.001 |
0.042 |
|
NAT1* |
2.15 (-0.42, 4.89) |
0.87 (0.8, 0.94) |
0.001 |
0.020 |
0.88 (0.81, 0.96) |
0.002 |
0.058 |
|
PTP4A2 |
-0.35 (-1.4, 0.95) |
0.76 (0.65, 0.89) |
0.001 |
0.020 |
0.79 (0.68, 0.93) |
0.004 |
0.071 |
|
SLC39A6* |
-0.38 (-2.45, 1.69) |
0.87 (0.8, 0.94) |
0.001 |
0.020 |
0.87 (0.81, 0.95) |
0.001 |
0.042 |
|
ESR1* |
4.27 (-0.96, 5.84) |
0.9 (0.85, 0.96) |
0.001 |
0.021 |
0.92 (0.87, 0.98) |
0.006 |
0.090 |
|
EVL |
0.68 (-0.56, 2.31) |
0.8 (0.69, 0.91) |
0.001 |
0.022 |
0.85 (0.75, 0.97) |
0.019 |
0.241 |
|
TBC1D9* |
0.15 (-1.87, 2.31) |
0.89 (0.83, 0.96) |
0.001 |
0.022 |
0.9 (0.84, 0.97) |
0.004 |
0.071 |
|
FUT8 |
-0.51 (-1.69, 0.68) |
0.82 (0.73, 0.93) |
0.002 |
0.026 |
0.82 (0.72, 0.92) |
0.001 |
0.042 |
|
SCUBE2 |
2.04 (-0.95, 4.18) |
0.89 (0.83, 0.96) |
0.002 |
0.028 |
0.91 (0.85, 0.98) |
0.009 |
0.131 |
|
GATA3 |
0.87 (-1.82, 2.15) |
0.89 (0.81, 0.97) |
0.007 |
0.080 |
0.9 (0.83, 0.99) |
0.022 |
0.256 |
|
MELK |
-2.53 (-3.47, -1.54) |
1.24 (1.06, 1.46) |
0.008 |
0.088 |
1.19 (1.02, 1.39) |
0.031 |
0.337 |
|
TCEAL1 |
0.45 (-0.95, 1.74) |
0.83 (0.72, 0.96) |
0.012 |
0.124 |
0.87 (0.76, 1) |
0.057 |
0.502 |
|
XBP1 |
2.69 (0.73, 3.66) |
0.87 (0.78, 0.98) |
0.021 |
0.197 |
0.89 (0.8, 1) |
0.055 |
0.502 |
|
PLK1 |
-2.5 (-3.32, -1.56) |
1.25 (1.02, 1.52) |
0.029 |
0.250 |
1.2 (0.99, 1.45) |
0.058 |
0.502 |
|
IL6ST |
-2.94 (-4.84, -0.45) |
0.92 (0.85, 1) |
0.045 |
0.363 |
0.95 (0.88, 1.02) |
0.166 |
1.000 |
|
DSC2 |
0.31 (-0.52, 1.71) |
1.1 (0.98, 1.24) |
0.099 |
0.759 |
1.09 (0.97, 1.22) |
0.170 |
1.000 |
|
CX3CL1 |
0.86 (-0.29, 2) |
1.11 (0.97, 1.27) |
0.123 |
0.890 |
1.07 (0.94, 1.22) |
0.314 |
1.000 |
|
ATAD2 |
-1.18 (-1.87, -0.56) |
1.08 (0.86, 1.35) |
0.521 |
1.000 |
1.15 (0.92, 1.44) |
0.230 |
1.000 |
|
BUB1 |
-3.1 (-4.23, -2.35) |
1.05 (0.88, 1.24) |
0.602 |
1.000 |
1.01 (0.86, 1.19) |
0.869 |
1.000 |
|
CENPA |
-2.18 (-3.06, -1.16) |
1.07 (0.9, 1.28) |
0.427 |
1.000 |
1.03 (0.86, 1.22) |
0.780 |
1.000 |
|
CKS2 |
-1.89 (-3.32, -0.95) |
0.99 (0.87, 1.13) |
0.925 |
1.000 |
0.97 (0.85, 1.11) |
0.678 |
1.000 |
|
GABRP* |
3.08 (0.38, 5.36) |
0.99 (0.93, 1.05) |
0.698 |
1.000 |
0.97 (0.91, 1.03) |
0.323 |
1.000 |
|
GMPS |
-1.4 (-2.22, -0.64) |
0.95 (0.79, 1.15) |
0.601 |
1.000 |
0.88 (0.74, 1.06) |
0.186 |
1.000 |
|
LRBA* |
-1.71 (-3.27, 0.67) |
0.99 (0.91, 1.09) |
0.871 |
1.000 |
1 (0.92, 1.09) |
0.986 |
1.000 |
|
MAPRE2 |
-1.84 (-2.84, -0.85) |
1.04 (0.88, 1.23) |
0.647 |
1.000 |
0.99 (0.84, 1.17) |
0.921 |
1.000 |
|
MCM6 |
-2.27 (-3.27, -1.43) |
0.96 (0.82, 1.14) |
0.655 |
1.000 |
0.95 (0.81, 1.11) |
0.545 |
1.000 |
|
PFKP |
-2.45 (-3.42, -1.46) |
1.13 (0.96, 1.33) |
0.152 |
1.000 |
1.05 (0.9, 1.23) |
0.539 |
1.000 |
|
ST8SIA1 |
-0.67 (-1.59, 0.58) |
1.02 (0.89, 1.17) |
0.795 |
1.000 |
1.02 (0.89, 1.17) |
0.769 |
1.000 |
|
TPBG |
0.68 (-0.38, 1.48) |
0.89 (0.75, 1.05) |
0.172 |
1.000 |
0.9 (0.76, 1.06) |
0.201 |
1.000 |
|
TRIM29 |
-0.71 (-2.74, 1.03) |
0.98 (0.9, 1.08) |
0.734 |
1.000 |
0.98 (0.9, 1.07) |
0.637 |
1.000 |
| YBX1 | -1.72 (-2.42, -1.12) | 1.1 (0.88, 1.36) | 0.413 | 1.000 | 1.04 (0.84, 1.29) | 0.702 | 1.000 |
Univariate hazard ratios (HRs), 95% confidence intervals (CIs), and unadjusted/adjusted p-values for disease mortality and recurrence are included. Q25 = 25th percentile, Q75 = 75th percentile.
ϮGenes ordered by adjusted p-value for mortality and then by gene name. *Genes which passed the permutation threshold for significance in the multivariable model, for both mortality and recurrence.