Table 2.
Changes in immuno-virological, haematological and metabolic markers, anthropometric and body composition parameters, and in bone markers as a function of treatment time
|
+ PI |
+ NNRTI |
||||||||
|---|---|---|---|---|---|---|---|---|---|
|
(n = 16) |
(n = 19) |
||||||||
| Parameter* | Month 0 | Month 9 | Month 21 | p, trend | Month 0 | Month 9 | Month 21 | p, trend | p, time X treatment interaction |
| CD4 lymphocytes /ml |
240 (153) |
376 (158) |
497 (189) |
0.001 |
241 (131) |
445 (167) |
493 (127) |
0.001 |
0.54 |
| Viral load, log10/ml |
5.05 (0.85) |
2.08 (0.85) |
1.62 (0.07) |
0.001 |
5.04 (0.55) |
1.91 (0.88) |
1.59 (0.01) |
0.001 |
0.99 |
| Cholesterol, g/l |
1.88 (0.45) |
2.22 (0.66) |
2.29 (0.41) |
0.001 |
1.61 (0.34) |
1.95 (0.46) |
2.03 (0.41) |
0.001 |
0.99 |
| HDL-cholesterol, g/l |
0.44 (0.08) |
0.45 (0.10) |
0.52 (0.15) |
0.06 |
0.38 (0.10) |
0.52 (0.16) |
0.56 (0.16) |
0.001 |
0.003 |
| Triglycerides, g/l |
1.14 (0.58) |
1.99 (1.68) |
1.75 (0.82) |
0.002 |
0.99 (0.48) |
1.34 (1.64) |
1.31 (0.97) |
0.26 |
0.06 |
| Glucose, g/l |
0.84 (0.08) |
0.88 (0.08) |
0.87 (0.07) |
0.14 |
0.83 (0.09) |
0.94 (0.08) |
0.90 (0.07) |
0.001 |
0.08 |
| Lactate, mmoles/l |
0.93 (0.28) |
1.06 (0.39) |
1.11 (0.44) |
0.24 |
0.98 (0.28) |
0.94 (0.24) |
0.93 (0.35) |
0.68 |
0.19 |
| Albumin, g/l |
39.0 (4.9) |
42.6 (2.0) |
42.5 (2.0) |
0.006 |
41.7 (3.7) |
43.1 (3.5) |
42.9 (2.5) |
0.07 |
0.05 |
| Cockroft (ml/min) |
83.9 |
82.9 |
86.1 |
0.73 |
102.3 |
103.1 |
104 |
0.66 |
0.97 |
| Waist circumference, cm |
83.2 (11.3) |
87.5 (16.7) |
89.7 (13.7) |
0.04 |
82.3 (7.4) |
82.5 (8.3) |
81.9 (9.1) |
0.51 |
0.03 |
| BMI, kg/m2 |
23.6 (3.6) |
25.0 (4.9) |
25.7 (5.5) |
0.02 |
23.9 (3.6) |
24.0 (3.7) |
24.3 (3.7) |
0.73 |
0.03 |
| Body Mineral content, kg |
3.02 (0.69) |
2.97 (0.63) |
2.93 (0.58) |
0.06 |
3.11 (0.56) |
3.08 (0.57) |
3.04 (0.53) |
0.008 |
0.58 |
| L2-L4 BMD, g/cm2 |
1.234 |
1.182 (0.226) |
1.186 (0.238) |
0.001 |
1.249 (0.178) |
1.232 (0.196) |
1.230 |
0.04 |
0.05 |
| (0.234) |
(0.176) |
||||||||
| Body lean mass, kg |
46.3 (8.8) |
48.2 (10.9) |
48.9 (11.2) |
0.05 |
49.4 (10.3) |
49.6 (9.6) |
49.8 (10.2) |
0.64 |
0.09 |
| Body fat mass, kg |
18.4 (8.9) |
20.2 (11.1) |
21.5 (10.4) |
0.02 |
19.4 (10.9) |
19.5 (10.2) |
19.6 (9.4) |
0.79 |
0.05 |
| Trunk fat mass, kg |
8.87 (4.38) |
9.43 (5.28) |
10.28 (4.80) |
0.03 |
9.03 (4.69) |
9.12 (4.57) |
9.49 (4.54) |
0.42 |
0.19 |
| Legs fat mass, kg |
6.61 (3.39) |
7.51 (4.16) |
8.00 (4.24) |
0.02 |
6.88 (4.18) |
7.29 (4.38) |
7.12 (3.70) |
0.35 |
0.07 |
| Total ALP U/l |
168 (37) |
193 (75) |
208 (82) |
0.04 |
173 (49) |
227 (67) |
221 (53) |
0.001 |
0.47 |
| Osteocalcin, μg/l |
19.3 (7.6) |
37.8 (15.0) |
29.7 (12.8) |
0.003 |
15.7 (5.1) |
24.5 (8.5) |
22.6 (12.6) |
0.005 |
0.19 |
| ß-crosslaps, μg/l |
353 (186) |
552 (267) |
525 (240) |
0.03 |
302 (161) |
582 (277) |
473 (226) |
0.001 |
0.56 |
| Calcium, mmoles/l |
2.28 (0.08) |
2.34 (0.10) |
2.36 (0.08) |
0.02 |
2.29 (0.11) |
2.32 (0.15) |
2.32 (0.13) |
0.31 |
0.22 |
| 25-OH vitamine D3, μg/l |
20.7 (8.2) |
22.1 (9.1) |
16.4 (7.2) |
0.27 |
19.4 (12.0) |
19.5 (12.7) |
15.7 (9.6) |
0.12 |
0.81 |
| 1,25—diOH-vit D3, ng/l |
49.1 (18.7) |
42.9 (8.3) |
58.9 (16.6) |
0.29 |
49.3 (18.4) |
51.6 (17.6) |
61.1 (14.7) |
0.04 |
0.54 |
| Parathormone, ng/l | 34.1 (12.9) | 36.7 (12.7) | 53.4 (20.0) | 0.01 | 35.1 (13.3) | 47.8 (19.6) | 46.5 (12.5) | 0.001 | 0.78 |
* mean value (standard deviation).