Table 2.
Results of adaptive resistant experiments of selected carbapenem-resistant Acinetobacter baumannii isolates
| Strain | PFGE group | MIC (mg/L) | Polymyxin B MIC of subpopulations selected in PAP | Highest concentration of polymyxin B where growth was observed (mg/L) | MIC after 3 days daily passages in drug-free medium (mg/L) | MIC after 60 days storage (mg/L) |
|---|---|---|---|---|---|---|
| 2 |
A |
≤ 0.125 |
2 |
64 |
32 |
NP |
| 3 |
A |
0.25 |
NA |
64 |
16 |
NP |
| 5 |
A |
0.25 |
1 |
NG |
NA |
NA |
| 6 |
A |
1 |
1 |
64 |
16 |
NP |
| 7 |
B |
≤ 0.125 |
0.5 |
64 |
16 |
NP |
| 8 |
B |
0.25 |
1 |
64 |
16 |
NP |
| 9 |
B |
≤ 0.125 |
0.5 |
64 |
16 |
NP |
| 10 |
C |
≤ 0.125 |
1 |
64 |
32 |
≤ 0.125 |
| 12 |
C |
≤ 0.125 |
1 |
64 |
16 |
NP |
| 14 |
D |
≤ 0.125 |
1 |
NG |
NA |
NA |
| 15 |
E |
0.25 |
1 |
NG |
NA |
NA |
| 16 |
F |
0.5 |
2 |
NG |
NA |
NA |
| 17 |
F |
≤ 0.125 |
1 |
NG |
NA |
NA |
| 18 |
G |
0.25 |
1 |
64 |
≥ 64 |
NP |
| 19 |
H |
0.25 |
1 |
NG |
NA |
NA |
| 20 |
I |
0.25 |
2 |
NG |
NA |
NA |
| 22 |
J |
0.25 |
1 |
64 |
16 |
0.25 |
| 23 |
K |
0.25 |
NA |
NG |
NA |
NA |
| 24 |
L |
≤ 0.125 |
0.5 |
64 |
16 |
≤ 0.125 |
| 26 |
M |
≤ 0.125 |
1 |
64 |
≥ 64 |
≤ 0.125 |
| 27 |
N |
0.5 |
2 |
NG |
NA |
NA |
| 29 | O | ≤ 0.125 | 1 | NG | NA | NA |
PAP population analysis profiles, NA not applicable, NG no growth, NP not performed.