Table 3. Binding Affinities and Titers of anti-PCSK9 variants.
Sequence ID | No of Clones | Average ka (1/M*s) | Average kd (1/s) | Average KD (nM) | Highest Titer (mg/L) |
---|---|---|---|---|---|
AX | 2 | 2.04E+05 | 8.66E-04 | 4.32±09 | 100 |
S2-10 | 4 | 2.40E+05 | 5.10E-04 | 2.14±0.2 | 550 |
S2-15 | 4 | 1.65E+04 | 1.12E-03 | 7.17±2.1 | 480 |