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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2013 May 17;12(7):1163–1170. doi: 10.1158/1535-7163.MCT-12-1092

Figure 3. CXCR4 blockade decreases VEGFA expression and in vitro angiogenesis.

Figure 3

JJ cells were cultured in hypoxia with CXCL12 (10 ng/mL), AMD3100 (5 μg/mL), or both. (A) VEGFA in media was measured with ELISA. Data are shown as mean ± SD for three replicates. (B) HUVEC were cultured with conditioned media from JJ cells and total length of tubular structures measured after twenty-four hrs. Data are shown as mean ± SD. *, # p<0.001, CXCL12 compared to control, AMD3100 or AMD3100 plus CXCL12 compared to CXCL12 alone.