Table 2.
Model results for the three nominally significant interactions (p<0.05)1 between adiposity related loci by MVPA2 in association with BMI-for-age Z scores, by race/ethnicity and main effects on BMI-for-age Z scores
| β (95% CI) | |
|---|---|
| European American | |
| FTO (rs9939609 per copy of A allele) | 0.23 (0.16, 0.30) |
| MVPA (high versus low) | 0.12 (0.02, 0.21) |
| rs9939609 × MVPA | −0.10 (−0.19, 0.21) |
| p for interaction1 | 0.024 |
| GNPDA2 (rs10938397 per copy of G allele) | 0.11 (0.03, 0.18) |
| MVPA (high versus low) | 0.12 (0.02, 0.22) |
| rs10938397 × MVPA | −0.09 (−0.18, −0.00) |
| p for interaction1 | 0.045 |
| Main effects | |
| FTO (rs9939609 per copy of A allele) | 0.16 (0.12,0.21) |
| MVPA (high versus low) | 0.04 (−0.03, −0.10) |
| GNPDA2 (rs10938397 per copy of G allele) | 0.05 (0.00, 0.09) |
| MVPA (high versus low) | 0.04 (−0.02, 0.11) |
| Hispanic American | |
| LZTR2/SEC16B (rs543874 per copy of G allele) | 0.29 (0.13, 0.46) |
| MVPA (high versus low) | 0.02 (−0.13, 0.17) |
| rs5438749 × MVPA | −0.33 (−0.55, −0.11) |
| p for interaction1 | 0.003 |
| Main effects | |
| LZTR2/SEC16B (rs543874 per copy of G allele) | 0.10 (−0.01, 0.21) |
| MVPA (high versus low) | −0.10 (−0.23, 0.03) |
Abbreviations: SNP, single nucleotide polymorphism, BMI, body mass index, MVPA, moderate to vigorous physical activity, CI, confidence interval
Beta estimates are presented for the SNP, MVPA, SNP by MVPA interaction terms, and main effects in the interacted multivariable linear model of adolescent BMI-for-age Z scores regressed on SNP, MVPA, and SNP-by-MVPA interaction, controlling for age, sex, current smoking, screen time, region, indicator for self-reported heights and weights, oversampling of highly educated African Americans (AA stratum only), Hispanic subpopulation ancestry, as well as an indicator for foreign born (HA stratum only). Random effects allowed for individual, family and school with no sample weighting. Models were run separately for each SNP and race/ethnicity. Likelihood ratio tests were used to assess statistical interaction between the main effects (no interaction term) model and the interaction model, separately for each SNP by race/ethnicity. P values corrected for multiple testing are α equal to 0.05/number of SNPs tested (0.0012 in EA and 0.0014 in HA).
High MVPA: 5 or more bouts per week of MVPA, low MVPA: less than 5 bouts per week of MVPA