Table 3.
Model results for the five nominally significant interactions (p<0.05)1 between adiposity related loci by MVPA2 in association with BMI-for-age Z scores in the race/ethnicity pooled meta-analysis sample3
| β (95% CI) | |
|---|---|
| FTO (rs9939609 per copy of A allele) | −0.43 (−0.76, −0.42) |
| p for interaction3 | 0.009 |
| GNPDA2 (rs10938397 per copy of G allele) | −0.42 (−0.08, −0.45) |
| p for interaction3 | 0.01 |
| POC5 (rs2112347 per copy of T allele) | −0.41 (−0.77, −0.35) |
| p for interaction3 | 0.03 |
| LYPLAL1 (rs2605100 per copy of the G allele) | 0.42 (0.80, 0.36) |
| p for interaction3 | 0.03 |
| TFAP2B (rs987237 per copy of G allele) | −0.44 (−0.01, −0.53) |
| p for interaction3 | 0.045 |
Abbreviations: SNP, single nucleotide polymorphism, BMI, body mass index, MVPA, moderate to vigorous physical activity, CI, confidence interval
Beta estimates are presented for the SNP, MVPA and SNP by MVPA interaction terms in the interacted multivariable linear model of adolescent BMI-for-age Z scores regressed on SNP, MVPA, and SNP-by-MVPA interaction, controlling for age, sex, current smoking, screen time, region, indicator for self-reported heights and weights, oversampling of highly educated African Americans (AA stratum only), Hispanic subpopulation ancestry, as well as an indicator for foreign born (HA stratum only). Random effects allowed for individual, family and school with no sample weighting. Models were run separately for each SNP and race/ethnicity. Likelihood ratio tests were used to assess statistical interaction between the main effects (no interaction term) model and the interaction model, separately for each SNP by race/ethnicity. P- value corrected for multiple testing is 0.0012.
High MVPA: 5 or more bouts per week of MVPA, low MVPA: less than 5 bouts per week of MVPA
Beta estimates are presented for the meta-analysis of race/ethnicity pooled sample estimates shown for SNP by MVPA interaction models in METAL [34]. The Z test was used to assess statistical interaction using comparison of SNP by MVPA interaction estimates.