Table 2.

FGFR3 mutation analysis of tumor samples and urothelial carcinoma cell lines.

Tumor samples
	Low grade	High grade	Total
Non-invasive	28/50 = 56%	2/18 = 11%	30/68 = 46%
Invasive	4/7 = 57%	10/95 = 11%	14/102 = 22%
Total	32/57 = 56%	12/113 = 11%	44/170 = 26%
Exon 7 mutation: 31 (70%)		Exon 10 mutation: 13 (30%)
Exon	Nucleotide position / base change	Codon / change in amino acid	N
7	746 C>G	S249C	31
10	1114 G>T	G372C	4
10	1117 A>T	S373C	1
10	1124 A>G	Y375C	7
10	1156 T>C	F386L	1

Cell lines
Cell line	Exon 7	Exon 10	Cell line	Exon 7	Exon 10
253J-P	wt	wt	UM-UC7	wt	wt
253J-BV	wt	wt	UM-UC10	wt	wt
RT4 v6	wt	wt	UM-UC11	wt	wt
RT112	wt	wt	UM-UC12	wt	wt
T24	wt	wt	UM-UC13	wt	wt
UM-UC1	wt	wt	UM-UC14	S249C	wt
UM-UC3	wt	wt	UM-UC15	S249C	Y375C
UM-UC4	wt	wt	UM-UC16	S249C	wt
UM-UC5	wt	wt	UM-UC17	S249C	wt
UM-UC6	R248C	wt