. Author manuscript; available in PMC: 2014 Sep 15.

Published in final edited form as: Int J Cancer. 2013 Apr 22;133(6):1300–1309. doi: 10.1002/ijc.28152

Table 1.

Mice with lesions in the oral cavity.

DB[a,l]PDE Treatment		Number of mice	Effective no. of mice^a	Hyperplasia	Dysplasia	Neoplasia			Others^b
DB[a,l]PDE Treatment		Number of mice	Effective no. of mice^a	Hyperplasia	Dysplasia	CIS	SCC	total	Others^b
Oral tissue	6 nmol/L	20	17	17 (100)^c,d,f	17 (100)	12 (71)^d,f	13 (76)^d,f	17 (100)^d,f	5 (29)^d,f
	3 nmol/L	20	19	19 (100)^d,f	19 (100)	14 (74)^d,f	14 (74)^d,f	17 (89)^d,f	3 (16)^e,g
	DMSO^h	20	19	14 (74)	18 (95)	0(0)	0(0)	0 (0)	0 (0)
	Untreated	20	18	12 (67)	17 (94)	0(0)	0(0)	0 (0)	0 (0)

Tongue	6 nmol/L	20	19	19 (100)^c,d,f	18 (95)^d,f	10 (53)^d,f	6 (32)^d,f	14 (74)^d,f	5 (26)^d,f
	3 nmol/L	20	20	20 (100)^d,f	20 (100)^d,f	7 (35)^d,f	3 (15)^d,f	9 (45)^d,f	1 (5)
	DMSO^h	20	20	12 (60)	11 (55)	0	0	0 (0)	0 (0)
	Untreated	20	19	11 (58)	10 (53)	0	0	0 (0)	0 (0)

Mice which died before the first tumor appeared in the study or did not reach histology due to cannibalism were not counted.

Others are primarily papillomas. In addition, we observed SCC in facial skin that can be considered HNSCC, but at lower incidence at about 20%.

Number in parentheses, percentage.

Significantly different from DMSO, p < 0.01.

Significantly different from DMSO, p < 0.05.

Significantly different from untreated, p < 0.01.

Significantly different from untreated, p < 0.05.

Previously reported in Ref. 18.