Table 2.

Mutational profiles of (±)-anti-DB[a,l]PDE-and B[a]P-induced mutations in tongue and other oral tissues: numbers and percentages of mutants

		(±)-anti-DB[a,l]PDE		B[a]Pa		Controlb
mutation class		number	%	number	%	%
transitions	GC:AT	7	11.8	15	31.3	63
	AT:GC	3	7.8	0	0	3
transversions	GC:TA	19	37.3	19	39.6	14
	GC:CG	8	15.7	5	10.4	3
	AT:CG	2	3.9	0	0	3
	AT:TA	10	19.6	2	4.2	6
in/delc		2	3.9	7	14.6	9
total		51	100	48	100	100

^aTongue and other oral tissues for B[a]P were obtained from a previous study (26). The MF in the cII gene for the tongues from the B[a]P treated mice was 15.7 ± 2.9 × 10^-5 vs. 2.1 ± 1.1 for control.

^bPercentage taken from ref. 18.

^cInsertions and deletions.