Table 3.
Modulation of gene expression by DB[a,l]P in mouse oral tissues.
| symbol | fold | description |
|---|---|---|
| 1. Cell Cycle Control and DNA Damage Repair | ||
| Ccne1 | 2.56 | Cyclin E1 |
| Cdk4 | 1.96 | Cyclin-dependent kinase 4 |
| Cdkn2a | 2.76 | Cyclin-dependent kinase inhibitor 2A |
| Chek2 | 3.10 | CHK2 checkpoint homolog (S. pombe) |
| E2f1 | 2.68 | E2F transcription factor 1 |
| 2. Apoptosis and Cell Senescence | ||
| Bax | 2.02 | Bcl2-associated X protein |
| Tert | 4.27 | Telomerase reverse transcriptase |
| Tnfrsf10b | 2.22 | Tumor necrosis factor receptor superfamily, 10b |
| 3. Signal Transduction Molecular and Transcription Factors | ||
| Fos | 4.77 | Interferon beta 1, fibroblast |
| Pik3r1 | 2.47 | Phosphatidylinositol 3-kinase, regulatory |
| 4. Adhesion | ||
| Itga2 | 3.01 | Integrin alpha 2 |
| Itgb3 | 2.36 | Integrin beta 3 |
| 5. Angiongenesis | ||
| Angpt1 | 3.02 | Angiopoietin 1 |
| Ifnb1 | 4.77 | FBJ osteosarcoma oncogene |
| Pdgfa | 2.55 | Platelet derived growth factor, alpha |
| 6. Invasion and Metastasis | ||
| S100A4 | 2.41 | S100 calcium binding protein A4 |
| Mta2 | 1.97 | Metastasis-associated gene family, member 2 |
| Mcam | 3.22 | Melanoma cell adhesion molecule |
| Serpine1 | 3.99 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 |
| Timp1 | 2.18 | Tissue inhibitor of metalloproteinase 1 |
| Kiss1 | 2.03 | KiSS-1 metastasis-suppressor |
| Muc1 | 2.25 | Mucin 1, transmembrane |
| Serpinb2 | -2.53 | Serine (or cysteine) peptidase inhibitor, clade B, member 2 |