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. 2013 Jul 5;9(6):637–648. doi: 10.7150/ijbs.6439

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 4 — RMP promotes the growth of HCC xenograft tumors in vivo. (A) SMMC-7721 HCC cells were inoculated subcutaneously for the tumor formation in nude mice as described in the Materials and Methods. The developed tumors in the mice were then treated with expression plasmids as indicated, or with PBS as a control. Finally tumors were dissected and photographs from each group are shown. (B) Tumor inhibition rate was indicated as percentage of growth reduction under each treatment relative to cells treated with PBS and represented by histogram. Student's t test, **, p<0.01, relative to controls. (C) The HCC xenograft tumors treated with expression plasmids as indicated or with PBS as a control were sectioned and subjected to H-E staining for pathological examination. (D) Immunohistochemical examination of RMP, AFP, Bax, Bcl-2 and p53 in the HCC xenograft tumors treated with expression plasmids as indicated, or with PBS as a control. (E) The percentage of positive cells expressing RMP, AFP, Bax, Bcl-2 and p53 was scored and represented by histogram.

Fig 4 — RMP promotes the growth of HCC xenograft tumors in vivo. (A) SMMC-7721 HCC cells were inoculated subcutaneously for the tumor formation in nude mice as described in the Materials and Methods. The developed tumors in the mice were then treated with expression plasmids as indicated, or with PBS as a control. Finally tumors were dissected and photographs from each group are shown. (B) Tumor inhibition rate was indicated as percentage of growth reduction under each treatment relative to cells treated with PBS and represented by histogram. Student's t test, **, p<0.01, relative to controls. (C) The HCC xenograft tumors treated with expression plasmids as indicated or with PBS as a control were sectioned and subjected to H-E staining for pathological examination. (D) Immunohistochemical examination of RMP, AFP, Bax, Bcl-2 and p53 in the HCC xenograft tumors treated with expression plasmids as indicated, or with PBS as a control. (E) The percentage of positive cells expressing RMP, AFP, Bax, Bcl-2 and p53 was scored and represented by histogram.