PCPT Algorithms
Variables
L2PSA = log base 2 transformed PSA in ng/ml
DRE = 1 (suspicious for prostate cancer) vs 0 (normal)
PriorBiop = 1 (ever prior biopsy negative for prostate cancer) vs 0 (otherwise)
FamHist = 1 (prostate cancer in father, brother or son) vs 0 (otherwise)
AA = 1 (black) vs 0 (otherwise)
Age = age in years
L2VOL = log base 2 transformed prostate volume in cc
NCORES = number of biopsy cores
AUASS = total AUASS on 7 questions (range 0 to 35)
PCPTRC_CLIN: risk of any prostate cancer
Score = 0.663 + 2.008L2PSA + 1.408DRE + 0.231FamHist − 0.567L2VOL − 0.241L2PSA × L2VOL + 0.056NCORES
PCPTHG_CLIN: risk of high grade disease (Gleason grade 7 or greater)
Score = −.979 + 1.169L2PSA + 1.117DRE + 1.018AA − 0.855L2VOL + 0.149NCORES
PCPTRC_AUA: risk of any prostate cancer
Score = −1.661 + 0.665L2PSA + 1.067DRE + 0.254FamHist − 0.532PriorBiop − 0.019AUASS
PCPTHG_AUA: risk of high grade disease (Gleason grade 7 or greater)
Score = −5.881 + 1.115L2PSA + 1.146DRE + 0.919AA − 0.594PriorBiop + 0.027Age − 0.035AUASS
Risk = exp(Score)/[1 + exp(Score)]