Table 2.
Risk factors for the event
| Explanatory variable | Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio | P-value | 95% CI | Hazard ratio | P-value | 95% CI | ||||
| Lower limit | Upper limit | Lower limit | Upper limit | ||||||
| Sex | Male/female | 1.18 | 0.0625 | 0.99 | 1.40 | 1.18 | 0.0685 | 0.99 | 1.42 |
| Age (years) | 1.01 | 0.0190 | 1.00 | 1.02 | 1.02 | <0.0001 | 1.01 | 1.03 | |
| Cause of liver cirrhosis | HBV (yes/no) | 1.01 | 0.9673 | 0.74 | 1.34 | ||||
| HCV (yes/no) | 0.86 | 0.0928 | 0.72 | 1.03 | |||||
| Alcohol (yes/no) | 1.16 | 0.1775 | 0.93 | 1.42 | |||||
| Treatment adherence (during 6 months) | Half or less/all | 1.74 | <0.0001 | 1.39 | 2.15 | 1.94 | <0.0001 | 1.54 | 2.42 |
| Previous hepatic cancer | Yes/no | 1.53 | <0.0001 | 1.25 | 1.86 | 1.76 | <0.0001 | 1.42 | 2.16 |
| Current clinical manifestations | Yes/no | 2.21 | <0.0001 | 1.84 | 2.65 | 1.66 | <0.0001 | 1.36 | 2.04 |
| Previous clinical manifestations | Yes/no | 1.88 | <0.0001 | 1.59 | 2.24 | 1.45 | <0.0001 | 1.20 | 1.74 |
| Diabetes | Yes/no | 1.24 | 0.0488 | 1.00 | 1.52 | ||||
| Serum albumin (g/dL) | Lower level | 2.51 | <0.0001 | 2.02 | 3.10 | 2.00 | <0.0001 | 1.57 | 2.54 |
| Platelet (×10 000/μL) | Lower level | 1.04 | <0.0001 | 1.02 | 1.06 | 1.03 | 0.0010 | 1.01 | 1.05 |
| AST (IU/L) | Higher level | 1.00 | 0.8840 | 1.00 | 1.00 | ||||
| ALT (IU/L) | Higher level | 1.00 | 0.0156 | 0.99 | 1.00 | ||||
| Serum total bilirubin (mg/dL) | Higher level | 1.68 | <0.0001 | 1.47 | 1.92 | 1.49 | <0.0001 | 1.29 | 1.72 |
| BTR | Lower level | 1.22 | 0.0839 | 0.98 | 1.59 | ||||
Univariate and multivariate analyses were performed using a Cox proportional hazards model, and hazard ratios, P-values and 95% CI of the hazard ratios are shown. For the multivariate analysis, variables were selected and determined by backwards selection (P = 0.2) using a model incorporating all factors except BTR. BTR was excluded from the multivariate analysis because a considerable proportion of patients lacked BTR data.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BTR, branched-chain amino acid/tyrosine ratio; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus.