Table 4.

List of Disease-Associated SNPs that are Predicted to have Significant Local Structural Effect (P < 0.1) Based on RNAfold with the Scores d_max and r_min

						P value
Disease/phenotype	Gene	HGMD Accession	GenBank Accession	NTs	SNP	P(dmax)	P(rmin)
Pseudohypoaldosteronism	NR3C2	CR030126	NM_000901.4	5,898	c.-2C>G	0.017	0.022
Hypertension	EDN2	CR994679	NM_001956.3	1,243	c.*390G>A	0.036	0.021
Obesity	CNR1	CR073542	NM_033181.3	5,373	c.*2394A>G	0.032	0.036
Myocardial infarction	GP1BA	CR022116	NM_000173.5	2,463	c.-5T>C	0.040	0.037
Colorectal cancer	INSR	CR082021	NM_001079817.1	9,023	c.*104A>G	0.042	0.030
Graves’ disease	FCRL3	CR067134	NM_052939.3	3,019	c.-11G>C	0.011	0.042
Increased triglyceride levels	ABCA1	CR025352	NM_005502.3	10,502	c.-279C>G	0.044	0.022
Insulin resistance and hypertension	RETN	CR032443	NM_020415.3	478	c.*62G>A	0.045	0.043
Cartilage-hair hypoplasia	RMRP	CR063417	NR_003051.3	268	n.215A>G	0.048	0.027
Hypercholesterolemia	LDLR	CR971948	NM_000527.4	5,283	c.-14C>A	0.025	0.048
Glaucoma	CYP1B1	CR032431	NM_000104.3	5,153	c.-286C>T	0.063	0.036
Reduced transcriptional activity	NR3C1	CR016150	NM_001024094.1	6,787	c.-219C>A	0.044	0.063
HDL cholesterol levels	LIPG	CR032437	NM_006033.2	4,141	c.*482A>G	0.051	0.065
Factor VII deficiency	F7	CR090334	NM_019616.2	3,059	c.-44T>C	0.066	0.042
Hemophilia A	F8	CR070421	NM_000132.3	9,035	c.-112G>A	0.074	0.010
Cartilage-hair hypoplasia	RMRP	CR064472	NR_003051.3	268	n.10T>C	0.076	0.024
Von Hippel–Lindau syndrome	VHL	CR011856	NM_000551.3	4560	c.*7C>G	0.076	0.065
Obesity	SLC6A14	CR035766	NM_007231.3	4,564	c.*178C>G	0.078	0.062
Spastic paraplegia 31	REEP1	CR082030	NM_022912.2	3,853	c.*14C>T	0.033	0.081
Hyperferritinemia-cataract syndrome	FTL	CR061334	NM_000146.3	871	c.-178T>G	0.052	0.097

The SNPs were described according to HGVS nomenclature. SNPs, which have been predicted to have significant global structural effect using SNPfold [Halvorsen et al., ²⁰¹⁰], are highlighted with gray background color.