Table 4.

MRIG-CBT plan results

A: Conventional plan results, target coverage
HR-CTV D 90	Conventional (% Rx)	MRIG-CBT (% Rx)	Diff. (%)	p -value
All plans	93 ± 24	91 ± 15	–7.6	0.421
Non-bulky	111 ± 16	98 ± 9	–9.2	0.002
Low-bulky	103 ± 16	97 ± 9	–6.2	0.101
Bulky	72 ± 17	80 ± 16	–7.7	0.028
B: Planning comparison, OAR sparring
	Conventional			MRIG-CBT			Diff. of % OAR limits	p -value
	D 0.1cc (Gy)	D 2cc (Gy)	% OAR limit	D 0.1cc (Gy)	D 2cc (Gy)	% OAR limit
Rectum
All plans	5.0 ± 1.7	3.7 ± 1.1	75 ± 34	4.2 ± 1.4	3.1 ± 1.0	56 ± 25	–19.0%	< 0.001
Non-bulky	5.1 ± 1.7	3.8 ± 1.3	80 ± 43	3.6 ± 1.2	2.5 ± 0.7	41 ± 16	–38.7%	< 0.001
Low-bulky	5.0 ± 2.0	3.7 ± 1.3	74 ± 32	3.9 ± 1.3	2.9 ± 0.8	50 ± 19	–24.1%	< 0.001
Bulky	4.9 ± 1.5	3.7 ± 0.9	72 ± 29	4.9 ± 1.4	3.7 ± 1.0	72 ± 26	–0.1%	0.893
Bladder
All plans	6.7 ± 2.2	5.1 ± 1.4	86 ± 36	6.3 ± 1.7	4.7 ± 1.3	75 ± 25	–11.4%	0.006
Non-bulky	5.9 ± 1.7	4.6 ± 1.5	78 ± 40	4.9 ± 1.6	3.6 ± 1.2	53 ± 28	–25.4%	< 0.001
Low-bulky	7.0 ± 1.8	5.3 ± 0.9	94 ± 34	6.5 ± 1.3	4.8 ± 0.9	78 ± 21	–15.2%	0.009
Bulky	7.1 ± 2.8	5.4 ± 1.6	85 ± 34	7.1 ± 1.6	5.5 ± 1.0	87 ± 16	2%	0.502
Sigmoid
All plans	5.1 ± 2.2	3.6 ± 1.1	73 ± 31	4.3 ± 1.9	3.0 ± 0.9	54 ± 23	–18.4%	< 0.001
Non-bulky	4.8 ± 1.4	3.5 ± 1.0	66 ± 21	4.0 ± 1.6	2.7 ± 0.9	44 ± 14	–22.0%	< 0.001
Low-bulky	4.7 ± 1.4	3.5 ± 1.1	72 ± 30	3.9 ± 1.3	2.9 ± 0.8	52 ± 21	–19.4%	< 0.001
Bulky	5.6 ± 3.1	3.8 ± 1.3	78 ± 38	4.9 ± 2.4	3.4 ± 1.0	64 ± 28	–14.8%	0.006

OAR – organ-at-risk, D_2cc, D_0.1cc – minimum dose to the hottest 0.1 cc or 2 cc of the OAR volume, Rx – prescribed dose, HR-CTV – high-risk clinical target volume, D₉₀ – minimum dose to the hottest 90% of the volume