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. 2013 Jul 11;3:182. doi: 10.3389/fonc.2013.00182

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Copyright © 2013 Haskins, Zablotsky, Foret, Ihrie, Alvarez-Buylla, Eisenman, Berger and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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c-Myc is expressed in the SVZ cell lineages. (A, B) c-Myc staining in SVZ (20×, coronal section); (C–E) Double labeling of c-Myc (red) and NSC marker – GFAP (C) as well as other lineage-specific markers showed c-Myc co-expressing with Mash1 (D), and DCX (E). Double-labeled cells were marked by arrows. LV: lateral ventricle; Str: striatum (12 μ coronal sections; 40× oil; scale bar = 50 μm). Anti-mitotic treatment abolished most of c-Myc expressing cells after Ara-C treatment; (F, G) Indicating c-Myc is highly expressed in progenitors and neuroblasts in SVZ.