Table 1.
Natural and induced Treg cells in cancer.
| Species | Cancer type/tumor model | Treg phenotype | Suggested origin | Origin indicator | Reference |
|---|---|---|---|---|---|
| Human | Ovarian carcinoma | CD4+FOXP3+; CXCR3+, T-bet+ | Natural | Helios expression | (41 ) |
| Human | Colon adenocarcinoma | CD4+FOXP3+; CCR4+CTLA-4hi | Unknown | (89 ) | |
| Human | Ovarian cancer | CD4+FOXP3+; Helios+, CCR4lo | Unknown | (61 ) | |
| Mice/Rats | Colon carcinoma/melanoma | CD4+CD25+/Foxp3+ | Natural | Expansion via mDC-TGF-β | (18 ) |
| Mice | Fibrosarcoma | CD4+Foxp3+ | Natural | Distinct TCR repertoire versus CD4+CD25− | (17 ) |
| Mice | Colon carcinoma | CD4+Foxp3+ | Induced | Foxp3 induction in CD4+CD25− | (20 ) |
| Mice | Renal cell carcinoma | CD4+CD25+/Foxp3+ | Induced | Foxp3 induction via TGF-β | (19 ) |
| Human | Renal cell carcinoma | CD4+FOXP3+ | Natural | Helios expression | (40 ) |
| Mice, human | Glioblastoma | CD4+Foxp3+ | Natural | Helios expression | (42 ) |
| Mice | Colon adenocarcinoma | CD4+Foxp3+; Nrp-1lo, Helioslo | Induced | Helios and Nrp-1 expression | (43 ) |
| Mice | Tumor cell line/melanoma | CD4+Foxp3+ | Natural | Distinct TCR sequence versus CD4+CD25− | (70 ) |
| Human | Hodgkin lymphoma | CD4+IL-10+ Tr1 and CD4+CD25+ | Unknown | (26 ) | |
| Human | Ovarian cancer | CD4+CD25−FOXP3−IL-10+ Tr1 and CD4+CD25+Foxp3+ | Induced and natural | IL-10 production or Foxp3 status | (30 ) |