Table I. Ingenuity analyses summary of Cort-BSA induced proteomic changes in CCRF-CEM cells.
| Data set | Top network | Scorec | Top functions | p value | Top canonical pathways | p value |
|---|---|---|---|---|---|---|
| 5 mina | Cell Death, Cellular Growth and Proliferation, Cancer | 17 | Cell death of tumor cell lines | 3.85E-05 | Glycolysis/Gluconeogenesis | 6.54E-04 |
| Apoptosis of lymphoma cell lines | 7.27E-05 | Purine Metabolism | 7.51E-04 | |||
| Apoptosis of tumor cell lines | 8.63E-05 | Oxidative Phosphorylation | 9.68E-04 | |||
| 15 mina | Cell Death, Cellular Development, Hematological System Development and Function | 12 | Cell death of lymphoma cell lines | 8.21E-05 | Aminoacyl-tRNA Biosynthesis | 3.73E-05 |
| Apoptosis | 1.69E-03 | Mitochondrial Dysfunction | 6.42E-04 | |||
| Apoptosis of lymphoma cell lines | 3.42E-03 | DNA Double-Strand Break Repair by Non-Homologous End Joining | 2.9E-03 | |||
| 90 mina | Cancer, Cell Death, Gastrointestinal Disease | 18 | Cell death of lymphoma cell lines | 1.26E-04 | Purine Metabolism | 3.56E-05 |
| Apoptosis of lymphoma cell lines | 3.89E-04 | RhoA Signaling | 1.51E-04 | |||
| Apoptosis of tumor cell lines | 8.72E-04 | Aminoacyl-tRNA Biosynthesis | 2.05E-04 | |||
| All | Cell Death, Cancer, Cell Cycle | 24 | Cell death of lymphoma cell lines | 8.25E-07 | Aminoacyl-tRNA Biosynthesis | 4.23E-06 |
| Apoptosis | 1.08E-05 | Purine Metabolism | 1.08E-05 | |||
| Apoptosis of lymphoma cell lines | 1.24E-05 | Glycolysis/Gluconeogenesis | 1.41E-05 | |||
| Cytosolb | Cancer, Cell Death, Reproductive System Disease | 13 | Accumulation of hydrogen peroxide | 4.70E-03 | Glycolysis/Gluconeogenesis | 1.72E-04 |
| Adhesion of endothelial cell lines | 4.70E-03 | Mitochondrial Dysfunction | 2.34E-04 | |||
| Permissivity of lymphoma cell lines | 4.70E-03 | Protein Ubiquitination Pathway | 3.91E-03 | |||
| Nucleusb | Cell Death, Cancer, Gene Expression | 19 | Cell death of lymphoma cell lines | 7.75E-08 | Aminoacyl-tRNA Biosynthesis | 1.09E-06 |
| Apoptosis of lymphoma cell lines | 1.84E-06 | RhoA Signaling | 3.77E-04 | |||
| Apoptosis | 3.18E-06 | DNA Double-Stand Break Repair by Non-Homologous End Joining | 3.9E-04 |
a Combined cytosol and nuclear fractions.
b Combined time points of 5, 15 and 90 minutes.
c Network scores ≥ 2 have at least a 99% confidence of not being generated by random chance.