Table II. Extracted ion current peak areas of salivary proteins/peptides of glandular origin determined in DS subjects and healthy controls (mean values ± S.D. ×10⁸).

Protein	Ctrlsa (n = 18)	Patientsa (n = 18)	p valueb	Ctrlsc (n = 18)	Patientsc (n = 18)	p valueb	Ctrlsd p value	Patientsd p value
PRP-1 2P	19.1 ± 13.7	15.2 ± 10.3	ns	40.7 ± 22.8	19.8 ± 8.1	0.001	0.002	ns
PRP-3 2P	5.5 ± 4.0	7.1 ± 6.1	ns	15.2 ± 9.5	8.4 ± 5.2	0.01	0.0002	ns
P-C	5.3 ± 4.2	8.4 ± 7.4	ns	13.3 ± 5.7	11.0 ± 10.0	ns	0.0001	ns
Hst-1	2.9 ± 1.9	2.2 ± 1.8	ns	3.4 ± 2.4	4.8 ± 5.0	ns	ns	0.04
Hst-3	0.7 ± 0.6	0.7 ± 0.8	ns	0.8 ± 1.5	1.6 ± 1.6	0.02	ns	ns
Hst-5	1.7 ± 1.1	3.0 ± 3.3	ns	2.3 ± 2.1	5.3 ± 4.0	0.019	ns	ns
Hst-6	0.8 ± 0.5	0.8 ± 0.9	ns	1.2 ± 2.0	2.2 ± 1.8	ns	ns	0.03
Cyst S	0.2 ± 0.3	0.1 ± 0.1	ns	0.5 ± 0.4	0.1 ± 0.2	0.0004	0.003	ns
Cyst S1	2.7 ± 3.9	1.3 ± 1.4	ns	6.6 ± 5.1	1.3 ± 1.7	0.0001	0.002	ns
Cyst S2	0.8 ± 1.3	0.3 ± 0.5	ns	1.6 ± 1.1	0.4 ± 0.8	0.0002	0.004	ns
Cyst SN	4.2 ± 6.2	3.5 ± 4.9	ns	12.0 ± 9.2	3.7 ± 6.2	0.001	0.001	ns
Cyst SA	1.0 ± 0.9	0.2 ± 0.3	0.004	1.4 ± 1.7	0.2 ± 0.3	0.002	ns	ns
Statherin	6.1 ± 4.1	7.8 ± 6.2	ns	9.5 ± 6.1	12.7 ± 12.0	ns	ns	ns
P-B	4.1 ± 2.7	9.3 ± 7.1	0.03	14.9 ± 8.3	15.4 ± 13.9	ns	<0.0001	ns

^a Age 10–17 yr group.

^b Controls vs DS subjects.

^c Age 18–50 yr group.

^d Age 10–17 vs age 18–50 yr group; ns: not significant.