Table I. Functional classification of the significantly altered proteins from CacyBP-OE data set. These proteins have met the criteria (i.e., unused protein score > 1.3 and change in expression level of at least 1.44-fold for HCT116-CacyBP OE vs. HCT116-Control cell) as defined in the “materials and method” as well as “results” section.

Unused Protein score	% Sequence Coverage	Accession Number	Name	Species	Peptides (95%)	Expression pattern	iTRAQ Ratio (Mean± S.E.)
Proteins involved in cellular proliferation
4.31	45.2	IPI00946824.1	FXN Uncharacterized protein	9606	2	↓	0.43 ± 0.05
12.51	22.1	IPI00795482.1	STAT1 83 kDa protein	9606	8	↑	2.44 ± 0.32
Proteins involved in cell Migration
23.1	17.1	IPI00215995.1	Isoform 1 of Integrin alpha-3	9606	18	↑	1.49 ± 0.18
14.86	23.9	IPI00921401.1	Isoform 9 of Integrin alpha-6	9606	11	↑	2.56 ± 0.04
10.99	24	IPI00555991.2	Isoform 2 of Integrin alpha-V	9606	9	↑	1.89 ± 0.15
48.23	35.1	IPI00220847.2	Isoform Beta-4D of Integrin beta-4	9606	34	↑	1.47 ± 0.03
10	37.8	IPI00719669.4	Myosin regulatory light chain MRCL2	9606	5	↑	1.52 ± 0.1
4.07	41.6	IPI00032313.1	S100A4 Protein	9606	2	↑	2.63 ± 0.2
12	73.2	IPI00297714.2	Gamma-synuclein	9606	9	↑	2.32 ± 0.08
12.51	22.1	IPI00795482.1	STAT1 83 kDa protein	9606	8	↑	2.45 ± 0.32
4	15.4	IPI00219301.7	Myristoylated alanine-rich C-kinase substrate	9606	2	↑	43.71 ± 21.65
22.22	76.3	IPI00219219.3	Galectin-1	9606	33	↓	0.62 ± 0.01
Proteins involved in cellular invasion
4	5.8	IPI01014165.1	COL18A1 Uncharacterized protein	9606	2	↑	1.83 ± 0.04
10.99	24	IPI00555991.2	Isoform 2 of Integrin alpha-V	9606	9	↑	1.89 ± 0.15
48.23	35.1	IPI00220847.2	Isoform Beta-4D of Integrin beta-4	9606	34	↑	1.47 ± 0.03
4	15.4	IPI00219301.7	Myristoylated alanine-rich C-kinase substrate	9606	2	↑	43.71 ± 21.65
16.4	49.1	IPI00647915.1	TAGLN2 24 kDa protein	9606	13	↑	1.73 ± 0.10
6.11	55.3	IPI01021488.1	CBX5, 22 kDa protein	9606	5	↓	0.54 ± 0.1
Proteins engaged in cellular adhesion
12.14	25.6	IPI00395605.4	ARHGEF1 Isoform 3 of Rho guanine nucleotide exchange factor 1	9606	7	↓	0.65 ± 0.07
11.89	29.5	IPI00301058.5	VASP Vasodilator-stimulated phosphoprotein	9606	11	↓	0.59 ± 0.02
Proteins involved in caveolar mediated endocytosis
23.1	17.1	IPI00215995.1	Isoform 1 of Integrin alpha-3	9606	18	↑	1.49 ± 0.18
14.86	23.9	IPI00921401.1	Isoform 9 of Integrin alpha-6	9606	11	↑	2.56 ± 0.04
10.99	24	IPI00555991.2	Isoform 2 of Integrin alpha-V	9606	9	↑	1.89 ± 0.15
48.23	35.1	IPI00220847.2	Isoform Beta-4D of Integrin beta-4	9606	34	↑	1.47 ± 0.03
Proteins involved in ARP-WASP mediated actin nucleation
23.1	17.1	IPI00215995.1	Isoform 1 of Integrin alpha-3	9606	18	↑	1.49 ± 0.18