Table II. Functional classification of the significantly altered proteins from CacyBP-KD dataset. These proteins have met the criteria (i.e. unused protein score > 1.3 and change in expression level of at least 1.57 fold for SW620-CacyBP KD vs. SW620-Scr Control cell) as defined in the “materials and method” as well as “results” section.

Unused Protein score	% Sequence Coverage	Accession Number	Name	Species	Peptides (95%)	Expression pattern	iTRAQ Ratio (Mean± S.E.)
Proteins involved in Cell proliferation
4	30.6	IPI00011590.1	Fos-related antigen 1	9606	2	↑	2.07 ± 0.25
2	9.5	IPI00013895.1	S100A11 Protein	9606	1	↑	1.72 ± 0.16
Proteins involved in focal adhesion
2.26	37.7	IPI00018451.6	Calcium and integrin-binding protein 1	9606	1	↑	1.70 ± 0.11
6	17.8	IPI00029834.3	Isoform 1 of Rhotekin	9606	3	↓	0.31 ± 0.04
4.01	13.4	IPI00014068.1	Isoform 1 of Serine/threonine-protein kinase PAK 4	9606	3	↓	0.62 ± 0.07
Proteins involved in cytoskeleton organization
6	60.6	IPI00791316.1	Neuromodulin isoform 1	9606	3	↑	2.63 ± 0.25
97.37	68.8	IPI00396171.4	Isoform 1 of Microtubule-associated protein 4	9606	74	↑	1.63 ± 0.05
27.5	58.2	IPI00000861.1	Isoform 1 of LIM and SH3 domain protein 1	9606	36	↑	1.60 ± 0.04
Proteins involved in integrin internalization
11.39	23.5	IPI00011285.1	Calpain-1 catalytic subunit	9606	7	↓	0.61 ± 0.07
8.89	25.9	IPI00556059.1	Isoform 2 of Chromosome-associated kinesin KIF4A	9606	6	↓	0.37 ± 0.05