Molecular evolution of lectin, 3FTx, epididymal secretory protein (A, B, and C, respectively), iguanian Cystatin (D), iguanian lizard and crotaline snake crotamines (beta-defensins) (E and F, respectively), iguanian lizard and Homalopsidae snake veficolins (G and H, respectively). The number of positively-selected sites (Codeml: Model 8, PP ≥ 0.95, Bayes-Empirical Bayes approach) and hypervariable regions are highlighted in red and orange, respectively. Various omega statistics (M8 omega value, total number of positively selected sites detected by M8 (PP ≥ 0.95, BEB)) and the number of positively and negatively selected sites detected by HyPhy integrative approach (SLAC and FEL: 0.05 significance; REL 50 Bayes factor) are also indicated.