Table II. Selection analyses of basal snake and Iguania venom-encoding genes.
| SLACa | FELb | RELc | Integrative analyses | MEME Sitesd | PAMLg | |||
|---|---|---|---|---|---|---|---|---|
| SLAC + FEL + REL + MEME | ||||||||
| Basal Snake | M8 | M2a | ||||||
| ω>1e | 0 | 2 | 65 | 66 | 40 | 20 | ||
| Lectins | ω<1f | 1 | 9 | 0 | 9 | 5 | (16 + 24) | (3 + 17) |
| ω = | 1.30 | – | – | – | 1.51 | 1.52 | ||
| ω>1e | 0 | 0 | 0 | 0 | ||||
| 3FTx | ω<1f | 0 | 4 | 10 | 11 | 0 | 0 | 0 |
| ω = | 0.48 | – | – | – | 0.77 | 0.77 | ||
| ω>1e | 0 | 0 | 0 | 1 | ||||
| ESP | ω<1f | 3 | 30 | 94 | 94 | 1 | 0 | 0 |
| ω = | 0.34 | – | – | – | 0.47 | 0.57 | ||
| Iguania | ||||||||
| ω>1e | 0 | 0 | 0 | 0 | ||||
| Cystatins | ω<1f | 0 | 8 | 0 | 8 | 0 | 0 | 0 |
| ω = | 0.42 | – | 48 | – | 0.55 | 0.47 | ||
3FTx, Three-finger Toxin; ESP, Epididymal Secretory Protein.
a Single Likelihood Ancestor Counting.
b Fixed-effects likelihood.
c Random-effects likelihood.
d Sites detected as experiencing episodic diversifying selection (0.05 significance) by the Mixed Effects Model Evolution (MEME).
e Number of positively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).
f Number of negatively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).
g Positively selected sites detected using the Bayes Empirical Bayes approach implemented in M8 and M2a. Sites detected at 0.99 and 0.95 significance are indicated in the parenthesis; ω: mean dN/dS.